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Calponin 2 Acts As an Effector of Noncanonical Wnt-Mediated Cell Polarization during Neural Crest Cell Migration
Authors:Bärbel Ulmer  Cathrin Hagenlocher  Silke Schmalholz  Sabrina Kurz  Axel Schweickert  Ayelet Kohl  Lee Roth  Dalit Sela-Donenfeld  Martin Blum
Affiliation:1. Institute of Zoology, University of Hohenheim, Garbenstrasse 30, 70593 Stuttgart, Germany;2. Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel
Abstract:
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  • Highlights? Cnn2 is expressed in NCCs and required for their migration in frogs and chicks ? Cnn2 is inactivated by noncanonical Wnt signaling ? Loss of Cnn2 causes a switch from cortical actin to central stress fibers ? Cnn2 polarizes the actin cytoskeleton downstream of PCP
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