1. Global Health Institute, School of Life Sciences, Station 19, EPFL, 1015 Lausanne, Switzerland;2. Bioinformatics and Statistics Core Facility, School of Life Sciences, Station 19, EPFL, 1015 Lausanne, Switzerland;3. Institute of Bioengineering, School of Life Sciences, Station 19, EPFL, 1015 Lausanne, Switzerland;4. Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK