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A Functional Variomics Tool for Discovering Drug-Resistance Genes and Drug Targets
Authors:Zhiwei Huang,Kaifu Chen,Jianhuai Zhang,Yongxiang Li,Hui Wang,Dandan Cui,Jiangwu Tang,Yong Liu,Xiaomin Shi,Wei Li,Dan Liu,Rui Chen,Richard   S. Sucgang,Xuewen Pan
Affiliation:1. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA;2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA;3. Division of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA;4. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA;5. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA;6. Institute of Biological Sciences and Biotechnology, Donghua University, Shanghai, 201620, China;7. Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
Abstract:
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  • Highlights? A functional variomics tool for drug-target identification is described ? This tool compares favorably with other target-identification tools ? This tool will greatly facilitate the linking of phenotypes to point mutations ? This work discovered Pmp3 as a target of amphotericin B
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