A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

Authors:	Masaharu Uno Sakiko Honjoh Mitsuhiro Matsuda Haruka Hoshikawa Saya Kishimoto Tomohito Yamamoto Miki Ebisuya Takuya Yamamoto Kunihiro Matsumoto Eisuke Nishida

Affiliation:	1. Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan;2. Career-Path Promotion Unit for Young Life Scientists, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan;3. Center for iPS Cell Research and Application, Institute for Integrated Cell-Material Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan;4. Department of Molecular Biology, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan

Abstract:	Download : Download full-size image Highlights? JNK/AP-1 signaling and DAF-16 play a central role in fasting-stimulus responses ? AP-1 and DAF-16 mediate induction of fasting genes that play key roles in life-span extension ? The SCF E3 ubiquitin ligase complex is a target of fasting-responsive signaling ? Fasting enhances protein ubiquitination, causing a reduction in protein carbonylation

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