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Iron Regulatory Proteins Control a Mucosal Block to Intestinal Iron Absorption

Authors:	Bruno Galy Dunja Ferring-Appel Christiane Becker Norbert Gretz Hermann-Josef Gröne Klaus Schümann Matthias W Hentze

Institution:	1. European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg 69117, Germany;2. Lehrstuhl für Tierernährung, Technical University München, Hochfeldweg 6, Freising 85354, Germany;3. Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim 68167, Germany;4. Deutsches Krebsforschungszentrum Heidelberg, Im Neuenheimer Feld 280, Heidelberg 69120, Germany;5. Lehrstuhl für Ernährungphysiologie, Technical University München, Gregor Mendelstrasse 2, Freising 85350, Germany

Abstract:	Download : Download full-size image Highlights? Disruption of intestinal IRP function constrains iron absorption in adult mice ? IRPs must limit mucosal ferritin for efficient iron absorption ? IRPs control ferroportin directly and DMT1 directly or through HIF2α ? IRPs define a set point for hepcidin-mediated regulation of iron absorption

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