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Silencing the Majority of Cerebellar Granule Cells Uncovers Their Essential Role in Motor Learning and Consolidation

Authors:	Elisa Galliano Zhenyu Gao Martijn Schonewille Boyan Todorov Esther Simons Andreea S Pop Egidio D’Angelo Arn MJM van den Maagdenberg Freek E Hoebeek Chris I De Zeeuw

Institution:	1. Department of Neuroscience, Erasmus MC Rotterdam, 3015GE Rotterdam, the Netherlands;2. Department of Human Genetics, Leiden University Medical Center, 2333ZA Leiden, the Netherlands;3. Department of Neurology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands;4. Department of Neuroscience and Brain Connectivity Center (BCC), University of Pavia and IRCCS C. Mondino, 27100 Pavia, Italy;5. Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts & Sciences, 1105BA Amsterdam, the Netherlands

Abstract:	Download : Download full-size image Highlights? Minimizing the output of cerebellar GCs impairs GC-PC long-term plasticity ? Minimizing the output of cerebellar GCs affects PCs’ coding ? Minimizing the output of cerebellar GCs does not compromise motor performance ? Minimizing the output of cerebellar GCs partially disrupts motor memory formation

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