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Disease-Association Analysis of an Inflammation-Related Feedback Loop
Authors:Masaaki Murakami  Masaya Harada  Daisuke Kamimura  Hideki Ogura  Yuko Okuyama  Noriko Kumai  Azusa Okuyama  Rajeev Singh  Jing-Jing Jiang  Toru Atsumi  Sayaka Shiraya  Yuji Nakatsuji  Makoto Kinoshita  Hitoshi Kohsaka  Makoto Nishida  Saburo Sakoda  Nobuyuki Miyasaka  Keiko Yamaguchi-Takihara  Toshio Hirano
Institution:1. Laboratory of Developmental Immunology, JST-CREST, Graduate School of Frontier Biosciences, Graduate School of Medicine, and WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;2. Department of Neurology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan;3. JST-CREST, Osaka University, Osaka 565-0871, Japan;4. Department of Medicine and Rheumatology, GCOE Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan;5. Department of Neurology, National Hospital Organization Toneyama Hospital, Osaka 560-0045, Japan;6. Health Care Center, Osaka University, Osaka 560-0043, Japan
Abstract:
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  • Highlights? The IL-6 amplifier is associated with various human diseases and disorders ? Genome-wide screens can isolate IL-6-amplifier-related genes ? These genes include those associated with human diseases ? Identified genes, e.g., the epiregulin-ErbB1 axis, may be therapeutic targets
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