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Foxg1 Coordinates the Switch from Nonradially to Radially Migrating Glutamatergic Subtypes in the Neocortex through Spatiotemporal Repression
Authors:Takuma Kumamoto  Ken-ichi Toma  William L McKenna  Takeya Kasukawa  Sol Katzman  Bin Chen  Carina Hanashima
Institution:1. Laboratory for Neocortical Development, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan;2. Functional Genomics Unit, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan;3. Department of Biology, Graduate School of Science, Kobe University, Kobe 657-8501, Japan;4. Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA;5. Center for Biomolecular Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Abstract:
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  • Highlights? Foxg1 directs projection neuron production onset in the neocortex ? Foxg1 acts cell autonomously to switch mammalian cortical subtypes ? Progenitors retain a prolonged competence to initiate corticogenesis in vivo ? Ebf2/3, Dmrta1, and Eya2 are mammalian-specific repression targets of Foxg1
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