Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

Authors:	Amede Larabi Juliette M Devos Sze-Ling Ng Max H Nanao Adam Round Tom Maniatis Daniel Panne

Institution:	1. EMBL Grenoble, 6 Rue Jules Horowitz, Grenoble 38042, France;2. Department of Molecular and Cellular Biology, Harvard University, Cambridge 02138, MA, USA

Abstract:	Download : Download full-size image Highlights? X-ray crystal structures of active and inactive human TBK1 kinase ? Structure in complex with specific inhibitors shows binding preferences ? The CTD is fully extended and constitutively interacts with adaptors ? Dimerization is required for kinase activation but not activity

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