Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Higher-Order Looping and Nuclear Organization of Tcra Facilitate Targeted RAG Cleavage and Regulated Rearrangement in Recombination Centers

Authors:	Julie Chaumeil Mariann Micsinai Panagiotis Ntziachristos Ludovic Deriano Joy M-H Wang Yanhong Ji Elphege P Nora Matthew J Rodesch Jeffrey A Jeddeloh Iannis Aifantis Yuval Kluger David G Schatz Jane A Skok

Institution:	1. Department of Pathology, New York University School of Medicine, New York, NY 10016, USA;2. NYU Center for Health Informatics and Bioinformatics, New York University School of Medicine, New York, NY 10016, USA;3. NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA;4. Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA;5. Department of Pathology and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA;6. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA;7. Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA;8. Institut Curie, CNRS UMR3215, INSERM U934, Paris 75005, France;9. Roche Nimblegen, Inc., Madison, WI 53719, USA

Abstract:	Download : Download full-size image Highlights? RAG-dependent monoallelic loop formation is linked to monoallelic RAG cleavage ? RAG enrichment, cleavage, and higher-order loop formation occur at the 3′ end of Tcra ? Looping out is a determinant of directed RAG targeting ? ATM-mediated control of looping out is linked to the maintenance of genome stability

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