RYBP and Cbx7 Define Specific Biological Functions of Polycomb Complexes in Mouse Embryonic Stem Cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

RYBP and Cbx7 Define Specific Biological Functions of Polycomb Complexes in Mouse Embryonic Stem Cells

Authors:	Lluis Morey,Luigi Aloia,Luca Cozzuto,Salvador Aznar Benitah,Luciano Di Croce

Affiliation:	1. Centre for Genomic Regulation and UPF, Dr. Aiguader 88, 08003 Barcelona, Spain;2. Institució Catalana de Recerca i Estudis Avançats, Pg. Lluis Companys 23, 08010 Barcelona, Spain

Abstract:	Download : Download full-size image Highlights? RYBP-PRC1 and Cbx7-PRC1 regulate a cohort of both common and specific sets of genes ? The presence of either RYBP or Cbx7 defines the biological function of PRC1 complexes ? PRC1-RYBP target genes are more highly expressed than PRC1-Cbx7 targets ? RYBP enhances PRC1 enzymatic activity, yet Cbx7 plays a pivotal role in PRC1 recruitment

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