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Human Complement Receptor Type 1/CD35 Is an Epstein-Barr Virus Receptor
Authors:Javier   G. Ogembo,Lakshmi Kannan,Ionita Ghiran,Anne Nicholson-Weller,Robert W. Finberg,George   C. Tsokos,Joyce   D. Fingeroth
Affiliation:1. Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;2. Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Abstract:
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  • Highlights? Human CD35, like CD21, binds EBVgp350/220, the major virion envelope glycoprotein ? CD35 mediates latent EBV infection when the fusion coreceptor HLA II is expressed ? Temperature, tempo, structure, and regulation distinguish CD35-mediated infection ? CD35 is a physiologically relevant EBV receptor
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