1. Laboratory of Behavioral and Developmental Genetics, Center of Human Genetics, University of Leuven, B3000 Leuven, Belgium;2. Laboratory of Computational Biology, Center of Human Genetics, University of Leuven, B3000 Leuven, Belgium;3. VIB Center for the Biology of Disease, B3000 Leuven, Belgium;4. INSERM U744, Institut Pasteur de Lille, Université de Lille Nord de France, 59019 Lille, France;5. Department of Neuroscience, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King’s College London, SE5 8AF London, UK;6. Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, VIB, B2610 Antwerpen, Belgium;7. Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, B2610 Antwerpen, Belgium
Abstract:
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Highlights? Gain or loss of dTDP-43 causes degeneration of neurons responsible for adult eclosion ? Gain or loss of dTDP-43 directly deregulates Map205 expression ? Map205-overexpression-defective EcR-dependent gene network switching ? dTDP-43-mediated neurodegeneration is caused by a loss of its normal function
