A recombination map of the human X-chromosome |
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| Authors: | R G Del Mastro P A Farndon Michael W Kilpatrick |
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| Institution: | (1) Department of Clinical Genetics, Birmingham Maternity Hospital, University of Birmingham, B15 2TG Birmingham, UK |
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| Abstract: | Summary A family with 11 normal boys has been typed with DNA probes spanning the whole of the X-chromosome to observe directly the recombination events in 11 meioses from one female. This has (a) identified apparent recombination hot-spots on the X-chromosome; (b) shown the positions and numbers of cross-overs that have occurred in the p and q arms; (c) not shown any cross-overs in the centromeric region and (d) enabled the calculation of the genetic length of the X-chromosome. |
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