Serum Bactericidal Activity of Trovafloxacin Against Selected Anaerobic Pathogens |
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| Institution: | 1. Department of Medicine, Michigan State University, Santa Monica, California;2. Michigan State University, RM Alden Research Laboratory, Santa Monica, California;3. UCLA School of Medicine, Los Angeles, CA;1. Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska institute, Stockholm, Sweden;2. Department of Infectious Diseases and Clinical Microbiology, University of Lund, Lund, Sweden;1. Laboratoire de microbiologie, institut mutualiste Montsouris, 75014 Paris, France;2. laboratoire de microbiologie, fondation hôpital Saint-Joseph, 75014 Paris, France;3. INSERMEP 99-22, CHUBichat-Claude Bernard, 75877Paris cedex 18, France;1. Laboratoire ORSTOM de Microbiologiedes Anaérobies, Université de Provence, CESB/ESIL Case 925, 163 Avenue de Luminy, 13288, Marseille, Cedex 09, France;2. Departamento de Biologia, Pontificia Universidad Javeriana, P.O.B 56710, SantaFe de Bogota, Colombia;3. Département de Biologia, Université de la Mediterranée, 13288, Marseille, Cedex 09, France;4. School of Biomolecular and Biomedical Sciences, Faculty of Science and Technology, Griffith University, Nathan, Brisbane, 4111, Australia;1. U.Z.Gasthuisberg, Laboratory of Experimental Radiobiology and Experimental Oncology, Herestraat 49, 3000, Leuven, Belgium;2. Laboratory of Bacteriology, Rega Institute, Minderbroedersstraat 10, 3000, Leuven, Belgium;3. Institute of Radiotherapy, Univ. Hosp. St. Radboud, Geert, Grooteplein 32, 6525, Nijmegen, The Netherlands;4. The Gray Laboratory, Cancer, P.O. Box 100, Middlesex, HA6 2JR, UK |
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| Abstract: | Trovafloxacin is a fluoroquinolone antimicrobial with improved in vitro activity against many anaerobic bacteria. We investigated the serum bactericidal activity of trovafloxacin against isolates of Bacteroides fragilis, Bacteroides thetaiotaomicron, Clostridium perfringens, and Peptostreptococcus magnus using a broth microdilution method. All procedures were performed in an anaerobic chamber. A single 200 mg oral dose of trovafloxacin was administered to six healthy volunteers and serum samples were obtained at 0, 2, 4, 6, 8, 10, 12 and 24 h post-dose. Bactericidal activity of these samples demonstrated that at 2 h all samples showed bactericidal activity against all four isolates. Prolonged bactericidal activity (12 to 24 h) was observed against three of the four isolates. Bactericidal activity was not observed after the first sampling period for the B. thetaiotaomicron strain. In this pharmacodynamic model, we found that trovafloxacin provided serum bactericidal activity against several common anaerobic pathogens associated with clinical infections. |
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