Desmutagenic substance in water extract of grass-wrack pondweed (Potamogeton oxyphylus Miquel) |
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| Authors: | T Sato Y Suzuki Y Ose T Ishikawa |
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| Institution: | Department of Environmental Hygiene, Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5 chome, Gifu City, Gifu, Japan |
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| Abstract: | It was found that the water extract of grass-wrack pondweed (Potamogeton oxyphylus Miquel) had inhibitory activity for reverse mutations induced by benzoa]pyrene, 2-aminoanthracene and 2-nitrofluorene with Salmonella typhimurium TA100 and TA98. The active substance was heat-resistant, and the molecular weight was above 300 000. The substance acted as a desmutagen rather than an antimutagen or inhibitor of metabolic activation. |
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| Keywords: | PB M/15 phosphate buffer at pH 7 0 |
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