The proteasome: not just degrading anymore |
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| Authors: | Baker Stephen P Grant Patrick A |
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| Affiliation: | Department of Biochemistry and Molecular Genetics, University of Virginia Schol of Medicine, Charlottesville, Virginia 22908, USA. |
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| Abstract: | The proteasome is a large multiprotein complex that has a critical role in the degradation of ubiquitylated proteins. A fascinating paper in this issue of Cell (Lee et al., 2005) now reveals that the proteasome recruits the SAGA histone acetyltransferase complex to a target promoter during gene activation. This finding adds to the growing body of evidence indicating that the proteasome has nonproteolytic functions. |
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