Retinal ganglion cell death and regeneration of abnormal retinotectal projections after removal of a segment of optic nerve in Xenopus tadpoles |
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Authors: | Lynda D Beazley |
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Institution: | Department of Psychology, University of Western Australia, Nedlands, Western Australia, 6009 Australia |
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Abstract: | Totally or partially disorganized visuotectal projections have been reported to develop following surgical manipulations in embryonic and larval Anura. Here it is shown that these are associated with a thin optic nerve arising from a retinal ganglion cell layer containing 20–30% of normal cell numbers, and entering the brain by the oculomotor nerve root. Such abnormal patterns of nerve growth have been found to result when a segment of optic nerve is removed. It is suggested that the abnormality represents a process of retinal ganglion cell death rather than a misprogramming of ganglion cell specificities as was previously hypothesized. |
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