Osteoclast precursor cells are present in the blood of preossification chick embryos |
| |
Authors: | Arnold J. Kahn David J. Simmons Marilyn Krukowski |
| |
Affiliation: | 1. Division of Bone and Mineral Metabolism, Schools of Medicine and Dental Medicine, Washington University, St. Louis, Missouri 63110 USA;2. the Department of Biology, Washington University, St. Louis, Missouri 63110 USA |
| |
Abstract: | In an attempt to ascertain the time of appearance of circulating osteoclast precursor cells, we have transplanted quail bone rudiments into or onto the extraembryonic membranes of variously aged chick embryos. We observed that osteoclast precursor cells (1) are present in the embryonic circulation prior to the onset of osteogenesis, (2) differentiate precociously in response to a factor or factors present in developing bone rudiments, and (3) increase in number until about midway in embryonic life. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|