| 人类线粒体DNA突变与癌症 |
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| 引用本文： | 张淑萍,宋书娟,李雅轩.人类线粒体DNA突变与癌症[J].遗传,2008,30(3):263-268. |
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| 作者姓名： | 张淑萍 宋书娟 李雅轩 |
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| 作者单位： | 1. 首都师范大学生命科学学院, 北京 100037;2. 北京大学医学部医学遗传学系, 北京 100083 ; |
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| 摘 要： | 细胞中的线粒体在细胞的能量代谢等功能中发挥了重要的作用。 人类的肿瘤形成与线粒体DNA (mtDNA)存在着复杂的关联, 在多种癌细胞中均检测到mtDNA的突变。文章综述了癌细胞中的mtDNA突变与癌症发 生的相关性, 并讨论了部分突变产生的原因及在癌症中进行mtDNA突变检测的应用前景。
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| 关 键 词： | 线粒体DNA 癌细胞 检测 突变 |
| 收稿时间： | 2007-09-30 |
| 修稿时间： | 2007年9月30日 |
Association between mitochondrial DNA mutations and cancer in human |
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| ZHANG Shu-Ping,SONG Shu-Juan,LI Ya-Xuan.Association between mitochondrial DNA mutations and cancer in human[J].Hereditas,2008,30(3):263-268. |
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| Authors: | ZHANG Shu-Ping SONG Shu-Juan LI Ya-Xuan |
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| Institution: | 1. College of Life Science, Capital Normal University, Beijing 100037, China;2. Department of Medical Genetics, Peking University Health Science Center, Beijing 100083, China ; |
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| Abstract: | Mitochondria are essential organelles that generate cellular energy in cells. Mutations of mitochondrial DNA (mtDNA) have been identified in various types of cancer, suggesting a complex relationship between mtDNA and cancer. This review focuses on the possible correlation between the mtDNA mutation and cancer. Additionally, possible causes for mtDNA mutations and applications for detecting mtDNA mutations in cancer are discussed. |
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