Assessing the reliability of eBURST using simulated populations with known ancestry |
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| Authors: | Katherine ME Turner William P Hanage Christophe Fraser Thomas R Connor Brian G Spratt |
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| Affiliation: | (1) Department of Infectious Disease Epidemiology, Imperial College, St. Mary's Hospital Campus, Norfolk Place, W2 1PG London, UK |
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| Abstract: | Background The program eBURST uses multilocus sequence typing data to divide bacterial populations into groups of closely related strains (clonal complexes), predicts the founding genotype of each group, and displays the patterns of recent evolutionary descent of all other strains in the group from the founder. The reliability of eBURST was evaluated using populations simulated with different levels of recombination in which the ancestry of all strains was known. |
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