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Chromosomal assignment of two putative canine keratin gene clusters |
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| Authors: | R C Keller M Switonski H Jörg D Ladon S Arnold & C Schelling |
| Institution: | Institute of Veterinary Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland,;Department of Genetics and Animal Breeding, Agricultural University of Poznan, 60-637 Poznan, Poland,;Department of Animal Science, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland,;Institute of Reproduction, University of Zurich, 8057 Zurich, Switzerland |
| Abstract: | Mutations in keratin genes account for a number of inherited keratodermas in humans. The groups of basic and acidic keratin genes are clustered on human chromosomes 12 and 17, respectively. The present authors have assigned the two putative keratin gene clusters to canine chromosomes using canine cosmid clones. Successful fluorescence in situ hybridization mapped the putative cluster of canine acidic genes to dog chromosome 20 and the putative cluster of basic keratin genes to a small autosome not yet included in the partial canine standard karyotype. |
| Keywords: | canine genetics physical mapping keratin genes |