Induction of abortion with intra-amniotic or intra-muscular 15(S)-15-methyl-prostaglandin F2α |
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Authors: | O Ylikorkala PA Jrvinen |
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Institution: | Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland |
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Abstract: | In order to evaluate the efficacy and acceptability of 15(S)-15-methyl-prostaglandin F2α (15-me-PGF2α) for pregnancy termination, we induced 30 abortions with single intra-amniotic injections of 2,5 mg of 15-me-PGF2α and 25 abortions with intra-muscular 15-me-PGF2α administered 200 g initially and 300 g every third hour until 30 hrs or abortion. Abortion occurred within 30 hrs in 97 % of cases in the intra-amniotic group, with a mean abortion time of 17,6 hrs and in 80 % in the intramuscular group, with a mean abortion time of 15.0 hrs. Neither parity nor gestational age was significantly related to the abortifacient efficacy of 15-me-PGF2α. No serious complications occurred. Vomiting (83–84 %) and diarrhoea (23–92 %) were the most common complaints. Uterine contractions were more painful if induction was effected with intra-amniotic rather than intramuscular injections. 15-me-PGF2α appears to be an effective and practicable abortifacient which can be used intra-amniotically or intramuscularly according to the ease of amniocentesis. |
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