Rapid formation of N-hydroxymethylpentamethylmelamine by mitochondria from rat small intestinal epithelium |
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| Authors: | P Borm M J Mingels A Hulshoff A Frankhuyzen-Sierevogel J Noordhoek |
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| Affiliation: | 1. Department of Pharmacology and Pharmacotherapy, Netherlands;2. Department of Analytical Pharmacy, Faculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511 GH Utrecht, The Netherlands |
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| Abstract: | Isolated rat intestinal mitochondria showed a considerable capacity to convert hexamethylmelamine to its monodemethylated metabolite pentamethylmelamine. Mitochondrial turnover rate is about the same as compared with microsomal preparations. Only in mitochondrial incubations N-hydroxymethylpentamethylmelamine could be identified as a metabolic intermediate. The known chemical reactivity of carbinolamines means that this activation pathway in mitochondria could be involved in the pharmacological or toxic effects of hexamethylmelamine. |
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