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Low molecular weight indole fragments as IMPDH inhibitors |
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| Authors: | Beevers Rebekah E Buckley George M Davies Natasha Fraser Joanne L Galvin Francis C Hannah Duncan R Haughan Alan F Jenkins Kerry Mack Stephen R Pitt William R Ratcliffe Andrew J Richard Marianna D Sabin Verity Sharpe Andrew Williams Sophie C |
| Affiliation: | UCB Celltech, Granta Park, Great Abington, Cambridge CB1 6GS, UK. |
| Abstract: | The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed. |
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