|
|||||
|
|
Taurine inhibits osteoblastic differentiation of vascular smooth muscle cells via the ERK pathway |
|
| Authors: | Xiao-bo Liao Xin-min Zhou Jian-ming Li Jin-fu Yang Zhi-ping Tan Zhuo-wei Hu Wei Liu Ying Lu Ling-qing Yuan |
| Institution: | (1) Department of Cardiothoracic Surgery, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China;(2) Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;(3) Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China |
| Abstract: | Vascular calcification develops within atherosclerotic lesions and results from a process similar to osteogenesis. Taurine is a free β-amino acid and plays an important physiological role in mammals. We have recently demonstrated that vascular smooth muscle cells (VSMCs) express a functional taurine transporter. To evaluate the possible role of taurine in vascular calcification, we assessed its effects on osteoblastic differentiation of VSMCs in vitro. The results showed that taurine inhibited the β-glycerophosphate-induced osteoblastic differentiation of VSMCs as evidenced by both the decreasing alkaline phosphate (ALP) activity and expression of the core binding factor α1 (Cbfα1). Taurine also activated the extracellular signal-regulated protein kinase (ERK) pathway. Inhibition of ERK pathway reversed the effect of taurine on ALP activity and Cbfα1 expression. These results suggested that taurine inhibited osteoblastic differentiation of vascular cells via the ERK pathway. |
| Keywords: | Taurine Vascular smooth muscular cells Extracellular signal-regulated kinases Osteoblast |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |