Interferon alters intracellular transport of vesicular stomatitis virus glycoprotein |
| |
| Authors: | V K Singh R K Maheshwari G P Damewood C B Stephensen C Oliver R M Friedman |
| |
| Affiliation: | Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD. |
| |
| Abstract: | Double-label immunofluorescence staining studies in virus-infected subclone 11 of LB cells indicated that almost all of the vesicular stomatitis virus (VSV) glycoprotein (G) was plasma membrane-associated during the logarithmic phase of virus replication. In contrast, treatment with interferon (IFN) resulted in inhibition of VSV-G transport, so that almost all of the G remained associated with the Golgi complex (GC) at comparable times after infection. In both IFN-treated and control cells, G was resistant to treatment with the enzyme endo-beta-N-acetylglucosamine H (endo H) indicating that the bulk of the G had reached the trans compartment of the GC. |
| |
| Keywords: | |
|
|
