Pentobarbital anesthesia: Lack of effect on venous prostaglandins in dogs |
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| Authors: | Harvey J. Berger Leon Speroff Steven Wolfson |
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| Affiliation: | Section of Cardiology, Department of Internal Medicine and Gynecologic-Endocrine Laboratory, Department of Obstetrics and Gynecology Yale University School of Medicine, 87-LMP, 333 Cedar Street, New Haven, Connecticut 06510 USA |
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| Abstract: | Venous prostaglandins A, E, and F were determined by radioimmunoassay in 10 dogs before and one hour after administration of sodium pentobarbital (35 mg/Kg, iv). In the conscious state, PGA was 0.34 ± 0.04 ng/ml (mean ± SE), PGE 0.20 ± 0.01 ng/ml, and PGF 0.25 ± 0.03 ng/ml. During pentobarbital anesthesia, these levels were unchanged (p >0.05). Thus, pentobarbital anesthesia had no effect on peripheral venous prostaglandin levels. |
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