Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA |
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Authors: | Xu Yufang Qu Baoyuan Qian Xuhong Li Yonggang |
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Affiliation: | Shanghai Key Lab. Chem. Biology, East China University of Science and Technology, Shanghai 200237, China. |
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Abstract: | Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (nicked) at a concentration as low as 10 microM and from form I to form III at a concentration of 50 microM. The results implied that the influence of intercalating ability of chromophores on photocleaving ability of photocleavers depended on the mechanism of photocleavage. |
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