Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma. |
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| Authors: | A M Jordan T H Khan H M Osborn A Photiou P A Riley |
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| Institution: | Department of Chemistry, University of Reading, Whiteknights, UK. |
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| Abstract: | A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired manner. Furthermore, differential cytotoxicity has been demonstrated in cell lines which express tyrosinase and those which do not. |
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