Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum |
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Authors: | Zhang Guojian Sun Shiwei Zhu Tianjiao Lin Zhenjian Gu Jingyan Li Dehai Gu Qianqun |
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Affiliation: | Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China. |
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Abstract: | Chemical investigation of the endophytic fungus Emericella sp. (HK-ZJ) isolated from the mangrove plant Aegiceras corniculatum led to isolation of six isoindolones derivatives termed as emerimidine A and B and emeriphenolicins A and D, and six previously reported compounds named aspernidine A and B, austin, austinol, dehydroaustin, and acetoxydehydroaustin, respectively. Their structures were elucidated on the basis of NMR spectroscopic evidence while the anti-influenza A viral (H1N1) activities of eight compounds were also evaluated using the cytopathic effect (CPE) inhibition assay. |
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