The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila |
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Authors: | Yanxia Li and Nicholas E Baker |
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Institution: | (1) Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10261, USA;(2) Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10261, USA |
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Abstract: | Background The receptor protein Notch and its ligand Delta are expressed throughout proneural regions yet non-neural precursor cells
are defined by Notch activity and neural precursor cells by Notch inactivity. Not even Delta overexpression activates Notch
in neural precursor cells. It is possible that future neural cells are protected by cis-inactivation, in which ligands block
activation of Notch within the same cell. The Delta-ubiquitin ligase Neuralized has been proposed to antagonize cis-inactivation,
favoring Notch activation. Cis-inactivation and role of Neuralized have not yet been studied in tissues where neural precursor
cells are resistant to nearby Delta, however, such as the R8 cells of the eye or the bristle precursor cells of the epidermis. |
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