RBP-J promotes the maturation of neuronal progenitors |
| |
| Authors: | Komine Okiru Nagaoka Mai Hiraoka Yuichi Hoshino Mikio Kawaguchi Yoshiya Pear Warren S Tanaka Kohichi |
| |
| Affiliation: | aLaboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan;bDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187-8502, Japan;cDepartment of Surgery and Surgical Basic Science, Kyoto University School of Medicine, Sakyo-ku, Kyoto 606-8507, Japan;dDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 1904, USA |
| |
| Abstract: | During brain development, neurons and glias are generated from neural stem cells and more limited intermediate neural progenitors (INPs). Numerous studies have revealed the mechanisms of development of neural stem cells. However, the signaling pathways that govern the development of INPs are largely unknown. The cerebellum is suitable for examining this issue because cerebellar cortical inhibitory neurons such as basket and stellate cells are derived from small Pax2+ interneuronal progenitors. Here, we show that Sox2−/Pax2+ and Sox2+/Pax2− progenitors, 2 types of interneuronal progenitors of basket and stellate cells, exist in the cerebellar white matter (WM) and that the former arise from the latter during the first postnatal week. Moreover, RBP-J promotes the neurogenesis of stellate and basket cells by converting Sox2+/Pax2− interneuronal progenitors to more mature Sox2−/Pax2+ interneuronal progenitors. This study shows a novel RBP-J function that promotes INP differentiation. |
| |
| Keywords: | Cerebellar development Basket cell and stellate cell Intermediate neural progenitor RBP-J Neurogenesis |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
