Interaction of bromine with iodine in the rat thyroid gland at enhanced bromide intake |
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Authors: | Miloslav Vobecký Arnošt Babický Jaroslav Lener Eva Švandová |
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Institution: | (1) Institute of Analytical Chemistry, Academy of Sciences of Czech Republic, Vídenská 1083, 142 20 Praha 4, Czech Republic;(2) National Institute of Public Health, 100 42 Praha 10, Czech Republic |
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Abstract: | In experiments with rats, we have found that at enhanced intake of bromide, bromine does not replace chlorine in the thyroid;
it replaces iodine. Under our experimental conditions, more than onethird of the iodine content in the thyroid was replaced
by bromine. In the thyroid, bromine probably remained in the form of bromide and, in proportional to its increased concentration,
the production of iodinated thyronines decreased, with the sum of the iodine and bromine concentrations being constant at
the value of 20.51±1.16 μmol/g dry wt of the thyroid. In contrast to other organs, the biological behavior of bromine in the
thyroid is not similar to the biological behavior of chlorine but resembles more that of iodine. |
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Keywords: | Chlorine bromine iodine interaction rat thyroid INAA |
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