Production of auto-anti-idiotypic antibody during the normal immune response: IX. Characteristics of the auto-anti-idiotype antibody and its production |
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| Authors: | Edmond A. Goidl Christiane Samarut Ansbert Schneider-Gadicke Neal L. Hochwald G.Jeanette Thorbecke Gregory W. Siskind |
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| Affiliation: | 1. Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York, New York 10021, U.S.A.;2. Department of Pathology, New York University Medical School, New York, New York 10016, U.S.A.;3. Department of Microbiology, University of Maryland School of Medicine, Baltimore, Maryland 21201 U.S.A. |
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| Abstract: | Using hapten-reversible inhibition of plaque formation as an assay for auto-anti-idiotype antibody (anti-Id) and as a means for following idiotype (Id) expression, we have obtained evidence that following immunization with trinitrophenyl (TNP) conjugates (a) there are differences in Id expression in the anti-TNP antibody response to different TNP conjugates although there is some overlap; (b) different strains, although showing some differences in Id expression, tend to produce cross-reactive Ids, thus no obvious allotype linked inheritance of Id expression is observed in this heterogeneous immune response; (c) the auto-anti-Id produced following immunization with TNP-Brucella abortus or TNP-Ficoll tends to be of the IgG2a and IgG2b isotypes. |
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| Keywords: | Address correspondence to Dr. Gregory Siskind Cornell University Medical College 1300 York Avenue New York N.Y. 10021. |
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