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Post-natal ontogenesis of graft-versus-host reactivity of peanut agglutinin lectin-negative thymocytes in the chicken |
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| Authors: | A. Torano E. Houssaint J. Ivanyi |
| Affiliation: | 1. Department of Experimental Immunobiology, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, United Kingdom;2. Abteilung Immunogenetik, Max Planck Institut fur Biologie, Tubingen, Germany;3. Institut National de la Santé et de la Recherche Médicale, Unité 211, Faculté des Sciences, 2 Rue de la Houssiniere, 44072 Nantes, Cedex, France |
| Abstract: | Chicken thymocyte fractionation by peanut agglutinin lectin yields two cell subpopulations which differ in their GvH competence when injected into major histocompatibility complex (MHC)-(B locus) incompatible embryos. The nonagglutinated PNA? fraction displayed a degree of alloreactivity similar to that of peripheral blood lymphocytes while the PNA+ cells were nonreactive. Analysis of chickens at the age of 4 to 24 weeks showed that the development of GvH-reactive PBL preceded by 12 weeks the maturation of GvH-reactive PNA? thymocytes. Possible interpretations for this difference between the time of appearance of GvH reactivity of PNA? thymocytes and PBL are discussed. |
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