Augmentation of the proliferative response of thymocytes to phytohemagglutinin by the muramyl dipeptide |
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Authors: | Hideaki Iribe Toshitaka Koga |
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Institution: | Department of Biochemistry, Kyushu University School of Dentistry 61, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan |
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Abstract: | A synthetic N-acetylmuramyl-l-alanyl-d-isoglutamine or muramyl dipeptide (MDP) and adjuvant-active analogs, but not lipopolysaccharide (LPS), exhibited the augmenting effect on the proliferative response of thymocytes to phytohemagglutinin (PHA). MDP also had a comitogenic effect on PHA-stimulated T lymphocytes. It was shown that the thymocyte-stimulating effect of MDP is not through the production of the monokines by MDP-stimulated macrophages and that MDP has a direct action on lymphocytes. |
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