Interleukin 2 (IL-2) activity during tumor growth: IL-2 production kinetics,absorption of and responses to exogenous IL-2 |
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Authors: | Carol J. Burger Klaus D. Elgert William L. Farrar |
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Affiliation: | Department of Biology, Microbiology Section, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 USA |
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Abstract: | A temporal study assessed the relationship between fibrosarcoma growth and immunologic encumberance due to the inability of BALB/c mouse splenocytes to elaborate the lymphokine Interleukin 2 (IL-2). Nylon-wool fractionation and antiserum treatments suggested the existence of a mildly nylon-wool-adherent, anti-Lyt 2-sensitive tumor-induced suppressor T (Ts,) cell which significantly decreased IL-2 activity. Absorption investigations indicated that ligand-activated tumor-bearing host (TBH) spleen cells were less receptive to IL-2 than their normal counterparts. When splenocytes were antiserum treated before absorption, removal of Lyt 2+ (suppressor T) cells resulted in greater IL-2 absorption by the remaining cells. Purified IL-2 only partially restored suppressed TBH spleen cell mitogen- or alloantigen-induced blastogenesis; whereas, normal host reactivity was significantly augmented. The collective data suggest that TBH spleen cells were capable of producing IL-2 and of responding to the IL-2 amplification signal when tumor-induced Ts cells were depleted. |
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Keywords: | To whom correspondence should be addressed. |
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