Natural killer activity of kurloff cells: A direct demonstration on purified kurloff cell suspensions |
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Authors: | Claire Debout Michèle Quillec Jacques Izard |
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Affiliation: | Laboratoire d''Histologie, UER de Médecine, CHU Côte de Nacre, 14032 Caen Cedex, France |
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Abstract: | In order to study their natural killer effect, guinea pig splenic Kurloff cells were fractionated by Percoll discontinuous density gradient centrifugation. Kurloff cells were collected and tested for cytotoxicity in a 24-hr chromium-release test. Comparison of different splenic cellular samples (of males or estrogenized females) with increasing percentage of Kurloff cells, revealed a highly significant positive correlation (r = 0.93, α < 0.01) with the cellular cytotoxicity developed against the K 562 target cells. |
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Keywords: | To whom correspondence should be addressed. |
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