Special symposium: In vitro plant recalcitrance loss of plant organogenic totipotency in the course of In vitro neoplastic progression |
| |
Authors: | Thomas Gaspar Claire Kevers Badia Bisbis Thierry Franck Michèle Crevecoeur Hubert Greppin Jacques Dommes |
| |
Affiliation: | (1) Biologie moléculaire et Hormonologie végétales, Institut de Botanique B 22, Univ. de Liège, Sart Tilman, B-4000, Liège, Belgium;(2) Physiologie végétale, Univ. de Genève, 3, pl. de l'Université, CH-1211 Genève, 4, Switzerland |
| |
Abstract: | Summary The aptitude for organogenesis from normal hormone-dependent cultures very commonly decreases as the tissues are serially subcultured. The reasons for the loss of regenerative ability may vary under different circumstances: genetic variation in the cell population, epigenetic changes, disappearance of an organogenesis-promoting substance, etc. The same reasons may be evoked for the progressive and eventually irreversible loss of organogenic totipotency in the course of neoplastic progressions from hormone-independent tumors and hyperhydric teratomas to cancers. As in animal cells, plant cells at the end of a neoplastic progression have probably undergone several independent genetic accidents with cumulative effects. They indeed are characterized by atypical biochemical cycles from which they are apparently unable to escape. The metabolic changes are probably not the primary defects that cause cancer, rather they may allow the cells to survive. How these changes, namely an oxidative stress, affect organogenesis is not known. The literature focuses on somatic mutations and epigenetic changes that cause aberrant regulation of cell cycle genes and their machinery. |
| |
Keywords: | plant cancer organogenic totipotency neoplastic progression habituation hyperhydricity oxidative stress |
本文献已被 SpringerLink 等数据库收录! |
|