Anthrax lethal toxin-induced mitogenic response of human T-cells |
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Authors: | Chantal Guidi-Rontani Edith Duflot Michele Mock |
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Affiliation: | Cooperative Research Centre for Food Industry Innovation, Department of Biotechnology, The University of New South Wales, Sydney, NSW 2052, Australia |
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Abstract: | Bacillus anthracis lethal toxin (PALF) stimulated the proliferation of human peripheral blood T-cells in vitro. Activation of T-lymphocytes by PALF required the presence of monocytes and did not result from a collaborative effect between T-cells and B-cells. PALF acted directly on monocytes and independently of T-cells. The monocytes contributed to the proliferation of T-cells by secretion of mediator(s). The mitogenic activity of the lethal toxin was dependent on its metalloprotease activity. |
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Keywords: | Nisin production transposon Lactococcus lactis Plasmid encoded nisin gene |
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