Structural relatedness of lysis proteins from colicinogenic plasmids and icosahedral coliphages |
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Authors: | Lau PC; Hefford MA; Klein P |
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Institution: | Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario. |
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Abstract: | The host-lysis-inducing functions of phi X174 protein E and MS2 protein L
were recently shown to reside on the N-terminal and C-terminal halves of
the two respective lysis proteins. In the present study it is shown that
the small lysis proteins encoded in various colicinogenic plasmids share
local sequence similarities and certain structural characteristics with the
essential peptides of their coliphage-coded counterparts. Despite their
dissimilar sizes and origins, it is suggested that the colicinogenic lysis
proteins are functionally analogous and evolutionarily related to those of
icosahedral single- stranded DNA and RNA phages.
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