消栓肠溶胶囊联合阿加曲班对急性脑梗死患者血液流变学和神经损伤指标的影响

目的:探讨消栓肠溶胶囊联合阿加曲班对急性脑梗死(ACI)患者血液流变学和神经损伤指标的影响。方法:选择2016年1月~2019年12月期间我院接收的ACI患者150例。按随机数表法分为对照组(常规药物及阿加曲班治疗,75例)及观察组(常规药物、阿加曲班及消栓肠溶胶囊治疗,75例)。比较两组临床疗效,Barthel指数、美国国立卫生研究院卒中量表(NIHSS)评分,治疗前后血液流变学及神经损伤指标变化情况,药物不良反应发生情况。结果:观察组总有效率高于对照组(P<0.05)。与对照组比较,治疗后观察组Barthel指数更高,而NIHSS评分更低(均P<0.05)。治疗后观察组纤维蛋白原、全血高/低切黏度、血浆黏度均低于对照组(均P<0.05)。治疗后观察组血清神经元特异性烯醇化酶(NSE)、神经胶质原纤维酸性蛋白(GFAP)及S100B蛋白水平均低于对照组(均P<0.05)。两组不良反应发生率无统计学差异(P>0.05)。结论:消栓肠溶胶囊联合阿加曲班治疗ACI的疗效较好,可显著改善患者血液流变学以及神经损伤指标水平。

Effects of Xiaoshuan Changrong Capsule Combined with Argatroban on Hemorheology and Nerve Injury Indexes in Patients with Acute Cerebral Infarction*

Objective:To investigate the effects of Xiaoshuan Changrong capsule combined with argatroban on hemorheology and nerve injury in patients with acute cerebral infarction(ACI).Methods:150 patients with ACI who were received in our hospital from January 2016 to December 2019 were selected,and they were randomly divided into control group(treated with conventional drugs and argatroban,75 cases)and observation group(treated with conventional drugs,argatroban and Xiaoshuan Changrong capsule,75 cases)by random number table method.The clinical efficacy,Barthel index,National Institutes of Health Stroke Scale(NIHSS)score,hemorheology and nerve injury indexes before and after treatment,and the occurrence of adverse drug reactions were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group(P<0.05).Compared with the control group,Barthel index in the observation group after treatment was higher,and NIHSS score was lower(all P<0.05).After treatment,fibrinogen,whole blood high/low shear viscosity and plasma viscosity in the observation group were lower than those in the control group(all P<0.05).After treatment,the levels of serum neuron specific enolase(NSE),glial fibrillary acidic protein(GFAP)and S100B protein in the observation group were lower than those in the control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Xiaoshuan Changrong capsule combined with argatroban is effective in the treatment of ACI,and which can significantly improve the level of hemorheology and nerve injury indexes.