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Glioma Pericytes Promote Angiogenesis by Producing Periostin |
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| Authors: | Bernardes Sara Santos Pinto Mauro Cunha Xavier Amorim Jaime Henrique Azevedo Vasco Ariston de Carvalho Resende Rodrigo Ribeiro Mintz Akiva Birbrair Alexander |
| Affiliation: | 1.Tissue Microenvironment Laboratory, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil ;2.Laboratory of Neuropharmacology and Neurochemistry, Institute of Biological Sciences, Federal University of Goiás, Goiania, GO, Brazil ;3.Center of Biological Sciences and Health, Federal University of West Bahia, Barreiras, BA, Brazil ;4.Cellular and Molecular Genetics Laboratory, Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil ;5.Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil ;6.Department of Radiology, Columbia University Medical Center, New York, NY, USA ; |
| Abstract: | Glioma is the prevalent aggressive primary brain tumor, with a very poor prognosis. The absence of advanced understanding of the roles played by the cells within the glioma microenvironment limits the development of effective drugs. A recent study indicates that periostin expressed by pericytes is crucial for glioma angiogenesis. Here, we describe succinctly the results and implications of this discovery in what we know about pericytes within the glioma microenvironment. The emerging knowledge from this work will benefit the development of therapies for gliomas. |
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