子宫内膜癌组织PRDM1、KIF23蛋白表达与临床病理特征及预后的关系研究

目的:探讨子宫内膜癌组织PR结构域蛋白1(PRDM1)、驱动蛋白家族成员23(KIF23)蛋白表达与临床病理特征及预后的关系。方法:选择2012年4月至2015年8月期间于我院行手术治疗的80例子宫内膜癌患者作为研究对象。检测子宫内膜癌组织以及癌旁组织中PRDM1、KIF23蛋白表达。分析PRDM1、KIF23蛋白表达与临床病理特征的关系。分析不同PRDM1、KIF23蛋白表达患者5年总生存率的差异。分析子宫内膜癌患者预后的影响因素。结果:与癌旁组织相比,子宫内膜癌组织中PRDM1、KIF23蛋白表达阳性率上调(P<0.05)。有淋巴结转移以及FIGO分期Ⅲ期患者的PRDM1、KIF23蛋白表达阳性率明显高于无淋巴结转移以及FIGO分期Ⅰ~Ⅱ期患者,组间差异显著(P<0.05)。PRDM1、KIF23蛋白阳性患者的5年总生存率明显低于PRDM1、KIF23蛋白阴性患者,组间差异显著(P<0.05)。Cox比例风险回归分析结果显示:PRDM1、KIF23蛋白表达、淋巴结转移、FIGO分期是子宫内膜癌患者预后的影响因素(P<0.05)。结论:在子宫内膜癌当中PRDM1、KIF23蛋白表达阳性率升高,有淋巴结转移、FIGO分期较高的患者PRDM1、KIF23表达阳性率上调,PRDM1、KIF23表达阳性患者5年总生存率下降。

Study the Relationship between PRDM1, KIF23 Protein Expression and Clinicopathological Features and Prognosis in Endometrial Carcinoma

Objective: To investigate the relationship between the PR domain containing 1(PRDM1), kinesin family member 23(KIF23) protein expression and clinicopathological features and prognosis of endometrial carcinoma. Methods: 80 patients with endometrial cancer who underwent surgery in our hospital from April 2012 to August 2015 were selected as the research objects. The PRDM1, KIF23 protein expression in the endometrial carcinoma and adjacent tissues were detected. The relationship between PRDM1,KIF23 protein expression and clinicopathological features were analyzed. The 5-year overall survival rate of patients with different PRDM1, KIF23 protein expression were analyzed. The prognostic influence factors of patients with endometrial carcinoma were analyzed. Results: Compared with the adjacent tissues, the positive rates of PRDM1, KIF23 protein expression in endometrial carcinoma tissues were up-regulated(P<0.05). The positive rates of PRDM1, KIF23 protein expression in patients with lymph node metastasis and FIGO stage Ⅲwere significantly higher than those in patients without lymph node metastasis and FIGO stage Ⅰ~Ⅱ(P<0.05). The 5-years overall survival rate of PRDM1, KIF23 protein positive patients was significantly lower than those of PRDM1, KIF23 protein negative patients, there were significant differences between groups(P<0.05). Cox proportional hazards regression analysis showed that PRDM1,KIF23 protein expression, lymph node metastasis, FIGO stage were the prognostic influence factors of patients with endometrial cancer(P<0.05). Conclusion: The positive rates of PRDM1, KIF23 in endometrial carcinoma are increased, and the positive rates of PRDM1,KIF23 are increased in patients with lymph node metastasis and high FIGO stage. The 5-year overall survival rate of PRDM1, KIF23 positive patients are decreased.