精神分裂症患者暴力行为与全脑皮质厚度、甲状腺功能和Th17相关炎症因子的相关性分析

目的:探讨精神分裂症患者暴力行为与全脑皮质厚度、甲状腺功能和辅助性T细胞17(Th17)相关炎症因子的相关性。方法:选择常德市康复医院2020年1月~2021年4月收治的精神分裂症患者82例为研究对象。采用修订版外显攻击行为量表(MOAS)评分将患者分成暴力组(n=37)与无暴力组(n=45)。比较两组全脑皮质厚度、甲状腺功能、Th17相关炎症因子水平,利用Pearson相关系数分析MOAS评分与全脑皮质厚度、甲状腺功能指标和Th17相关炎症因子的相关性。结果:暴力组左侧枕中回、顶上回、顶下角回、顶下缘上回、枕极以及右侧枕上回、顶上回、顶下角回、顶下缘上回皮质厚度低于无暴力组(P<0.05)。暴力组血清游离三碘甲状腺原氨酸(FT₃)、总甲状腺激素(TT₄)、游离甲状腺素(FT₄)、总三碘甲状腺原氨酸(TT₃)、促甲状腺激素(TSH)、白介素-17(IL-17)、白介素-23(IL-23)、转化生长因子-β1(TGF-β1)水平高于无暴力组(P<0.05)。Pearson相关性分析结果显示,精神分裂症患者MOAS评分与左侧枕中回、顶上回、顶下角回、顶下缘上回、枕极以及右侧枕上回、顶上回、顶下角回、顶下缘上回皮质厚度呈负相关,与血清FT₃、TT₄、FT₄、TT₃、TSH、IL-17、IL-23、TGF-β1水平呈正相关(P<0.05)。结论:有暴力行为的精神分裂症患者伴有明显的全脑皮质厚度降低与甲状腺功能指标、Th17相关炎症因子水平升高,这可能对此类患者暴力行为的防治有一定参考意义。

Correlation Analysis between Violent Behavior and Whole Cerebral Cortex Thickness, Thyroid Function and Th17 Related Inflammatory Factors in Patients with Schizophrenia

Objective:To investigate the correlation between violent behavior and whole cerebral cortex thickness,thyroid function and helper T cell 17(Th17)related inflammatory factors in patients with schizophrenia.Methods:82 patients with schizophrenic who were treated in Changde Rehabilitation Hospital from January 2020 to April 2021 were selected as the research objects.The patients were divided into violence group(n=37)and non violence group(n=45)by the modified overt aggression scales(MOAS)score.The whole cerebral cortex thickness,thyroid function and Th17 related inflammatory factors were compared between the two groups.Pearson correlation coefficient was used to analyze the correlation between MOAS score and whole cerebral cortex thickness,thyroid function and Th17 related inflammatory factors.Results:The cortical thickness of the left middle occipital gyrus,superior parietal gyrus,inferior parietal angular gyrus,superior gyrus of inferior parietal margin,occipital pole and right superior occipital gyrus,superior parietal gyrus,inferior parietal angular gyrus and superior gyrus of inferior parietal margin in the violence group was lower than that in the non violence group(P<0.05).The levels of serum free triiodothyronine(FT₃),total thyroid concentration(TT₄),free thyroxine(FT₄),total triiodothyronine(TT₃),thyroidstimulating hormone(TSH),interleukin-17(IL-17),interleukin-23(IL-23),transforming growth factor-β1(TGF-β1)in the violent group were higher than those in the non violent group(P<0.05).Pearson correlation analysis showed that the MOAS score of patients with schizophrenic was negatively correlated with the cortical thickness of the left middle occipital gyrus,superior parietal gyrus,inferior parietal angular gyrus,superior gyrus of inferior parietal margin,occipital pole and right superior occipital gyrus,superior parietal gyrus,inferior parietal angular gyrus and superior gyrus of inferior parietal margin,and it was positively correlated with the levels of serum FT₃,TT₄,FT₄,TT₃,TSH,IL-17,IL-23 and TGF-β1(P<0.05).Conclusion:Schizophrenic patients with violent behavior are accompanied by obvious decrease of whole cerebral cortex thickness and increase of thyroid function and Th17 related inflammatory factors.which may be of certain reference significance for the prevention and treatment of violent behavior in patients.