Disturbance of lymphocyte circulation byPseudomonas aeruginosa infection in oxazolone-sensitized mice |
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Authors: | Mario Campa Eleuterio Ferrannini Carlo Garzelli Vittorio Colizzi Giuseppe Falcone |
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Institution: | (1) Istituto di Microbiologia, Universitá di Pisa, Via S. Zeno, 39, 56100 Pisa, Italy;(2) Laboratorio di Fisiologia Clinica del C.N.R., Via Savi, 8, 56100 Pisa, Italy |
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Abstract: | Pseudomonas aeruginosa infection depresses contact sensitivity to oxazolone in mice. To test whether an altered lymphocyte circulation plays a role
in this depression51Cr-labeled lymphocytes fromP. aeruginosa-infected and oxazolone-sensitized donors were injected intravenously into infected and sensitized recipients, and the radioactivity
uptake of several organs was determine. The controls consisted of normal mice receiving labeled lymphocytes from normal donors.
While the radioactivity recovered from the liver, spleen, and mesenteric lymph nodes was similar in the test and the control
group, significantly more radioactivity was recovered from the draining lymph nodes of infected and sensitized recipients.
The concentration of labeled lymphocytes from sensitized donors in the draining lymph nodes of sensitized recipients was 18%
greater than that of the controls but 31% lower than that of infected and sensitized animals receiving cells from infected
and sensitized donors.P. aeruginosa infection enhances lymphocyte entrapment within the draining lymph nodes of oxazolone-sensitized mice. |
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