Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain |
| |
| Authors: | Varghese S Shameena B Lakshmy P S Biju M P Easwar Shankar P N Paulose C S Oommen O V |
| |
| Affiliation: | Department of Zoology, University of Kerala, Kariavattom, Thiruvanantpuram, India. |
| |
| Abstract: | The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T3) (2.5 microg/100 g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-hydroxytryptophan (5-HTP), serotonin (5-HT), 5-hydroxy indole acetic acid (5-HIAA), norepinephrine (NE) and epinephrine (EPI) contents were assayed in the hypothalamus and cerebral cortex regions. It was found that 6-PTU feeding resulted in decrease in dopamine, 5-HT, 5-HTP and 5-HIAA in both regions. In animals fed with PUFA followed by administration of T3, the DA level was found normal. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
