Synthesis of RGD amphiphilic cyclic peptide as fibrinogen or fibronectin antagonist |
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| Authors: | Mamadou Amadou Sow, Annie Molla, Fré dé ric Lamaty René Lazaro |
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| Affiliation: | (1) Laboratoire des Aminoacides, Peptides et Protéines CNRS ESA 5075, Université de Montpellier II, F-34095 Montpellier Cedex, France;(2) Laboratoire Etude de l'Adhésion Cellulaire, CNRS UMR 5538, Institut Albert Bonniot, F-38706 La Tronche, France |
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| Abstract: | This paper investigates the effect of the incorporation of adiazaethylene glycol derivative (Deg, 2) into a cyclic peptide containingthe tripeptide sequence Arg-Gly-Asp (RGD). This motif is a common structuralelement of many integrin ligands. The synthesis of cyclo-(Arg-Gly-Asp-Deg)(7) has been accomplished in solution using standard peptide chemistry. Theintent was to improve the bioavailability of this new RGD cyclic peptide,which is shown to interact with  IIb 3 3or 5 1 receptors. A preliminary stepfor the conformational study of peptide 7 was done in DMSO-d6using nuclear magnetic resonance spectroscopy techniques. |
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| Keywords: | Aggregometry Cyclic peptide Diazaethyleneglycol derivative HEL cell adhesion RGD peptide |
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