Cellular immune response of SIV-infected rhesus macaques |
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Authors: | T P McGraw B R Vowels M E Gershwin M B Gardner |
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Affiliation: | Department of Medical Pathology, University of California, Davis. |
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Abstract: | Optimal conditions for the assessment of T cell proliferation and cytolytic T lymphocyte (CTL) responses specific for primate lentivirus were established. CTL and T cell proliferative responses were demonstrated as early as two weeks post-infection. Although the majority of CTL were CD8+, MHC class I-restricted, this study demonstrated CD4+, MHC class II-restricted CTL. Experiments also demonstrated that CTL were CD16 negative. Target cell generation could be blocked with CD4 mAb specific for the SIV binding site. |
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Keywords: | Acquired immunodeficiency syndrome Cytotoxic T lymphocyte Helper T lymphocyte |
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